High-throughput, automated, Dynamic and Static Light Scattering Revolutionize your performance by replacing your conventional, cuvette-based dynamic light scattering unit with the automated DynaPro® Plate Reader III. The DynaPro excels at high-throughput sizing and screening of pharmaceutical and nanoparticle formulations to enable novel workflows that simply would not be possible with other DLS instruments. Even if you need to run just a handful of samples, it's a great productivity booster. For biotherapeutic development, the DynaPro Plate Reader is a comprehensive solution for stability evaluation.

Measure aggregation, aggregate size distributions, changes in solution molecular weight, and propensity for aggregation: indicators of both thermal stability (T onset, T m, T agg) and colloidal stability (A 2/B 22, k D) may be quantified with plate-based DLS and SLS. Even viscosity of concentrated protein solutions can be screened across dozens of formulations in a single plate.

The DynaPro Plate Reader is accompanied by, our powerful software package for analyzing automated batch dynamic light scattering. The Security Pack (DYNAMICS SP) option provides 21 CFR (11) compliance for GMP/GLP use. Revolutionize DLS The DynaPro Plate Reader offers dynamic light scattering (DLS) and static light scattering (SLS) measurements of the size, molecular weight and interactions of proteins, nanoparticles and other macromolecules in situ in industry-standard microwell plates. No liquid handling occurs after dispensing into the plates, to maximize throughput and minimize sample carryover. This ground-breaking instrument provides rapid optimization of the formulation process for: • such as monoclonal antibodies and virus-like particles (VLPs) • drug delivery vehicles including liposomes and conjugated gold NPs • drug particles. Key features • Measure hydrodynamic radius from 0.5 nm to 1000 nm • Sensitivity for size down to 0.125 mg/mL lysozyme • Measure weight-average molar mass from 1 to 1000 kDa • Industry standard microwell plates of 96, 384 or 1536 wells • Sample volume from 4 μL to 150 μL • All measurements made in situ in the wells • Temperature ramps from 4°C to 85°C • Integrates with plate-based liquid handling robotics • See how easy it is to make measurements with the DynaPro Plate Reader, courtesy of Yale University Chemical and Biophysical Instrumentation Center.

• • A wealth of features • Rapid or slow temperature ramps 4°C - 85°C with excellent uniformity across the plates. Samples are heated in parallel and all filled wells measured at each temperature. • Well read times as short as 5-10 seconds • Seal wells with oil or sealing tape to prevent evaporation. The tape is gently heated to prevent condensation. • Integration with liquid-handling robots for higher levels of automation, especially when your workflow is plate-based, and utilizes spectroscopic and other plate readers in addition to DLS/SLS • A camera for viewing each well from below, to aid in data diagnostics (e.g.

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To detect precipitation or bubble formation) • A set of images collected by the onboard camera, showing clean wells and wells containing bubbles, crystals and precipitates. • • Lab automation An OLE software API is available for interfacing the DynaPro Plate Reader to robotic liquid handling in the high-throughput lab. This capability allows for fully automated plate loading and data collection. Wyatt partners with several companies that offer integrated solutions for automated loading and analysis of plated samples: • Hudson Robotics Plate Transfer Click to play video • In addition, Hamilton Robotics, Caliper Life Sciences, and Tecan offer custom integration services. • - Makes it easy to filter, recover and refilter precious sample.

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This is especially useful when your total sample volumes are below 300 µL. • - Automates well-plate scans, temperature ramps, etc. And analyzes DLS data to determine size distributions, temperature onset of melting or aggregation, second virial coefficient A 2and the diffusion interaction parameter k D.